What is bore and stroke currently? I got lost following the numbers in your post. Also is this thing Blown Alky currently or just N/A? Other thing to consider is what is your realistic comfort zone on Max RPM on a run? Bore and stroke changes do make a difference on shape of power curve as does cam timing and head flow.
4.250 going to 4.310 or 4.375 bore/ Rpm not a concern motor use to be spun at 11.000 when had screw blower on it and these rods are better than one I had then. Not going 11k probably 8500 max but 9500 would not worry me.
Headflow is around 540 at .800 if memory serves. N?a but with nitro at times. Cam is 289/292 at .050 with .825 lift.
Stroke is 4.250 and may drop the 4.50 in,just not wanting to buy new rods at 1500 a set and have new set. Rods are .340 over stock and could drop back to .220 over if goin g to 4.50 crank and use same pistons. With big influx, I could just build both. Anybody have more than you need?LOL at 511 and 540 ci just need money.
Compression is 12:1 going to 15:1 with .040 gasket and dwon to around 13.5: with gasket changes.