E85 popular here in Colorado. Out on the eastern plains of Colorado, they grow corn specifically for ethanol blended fuel. From memory, there are 3 classes of ethanol fuel, Class 1 is 85% ethanol and 15% gas, octane is around 104-105. Class 2 and 3 are less percent of ethanol and higher percent gas, like 70-75% ethanol to 25-30% gas. Octane goes down with more gas percent.
I’ve run mechanical fuel injection, both methanol and a nitro mix, not E85. If your combustion chamber burns all the fuel and air mixture, you just reached stoichiometric or stoich, a good thing. Here are some general stoich values for different fuels:
Pump gas.............14.7:1
C16 race gas.........14.8:1
E85........................9.8:1
Methanol.................6.4:1
Answer to your question, yes you can run E85, you will need to make tuning changes. To achieve the E85 9.8:1 stoich from your current Methanol 6.4:1 stoich, you will need to increase your main pill (area) to reduce fuel flow to your combustion chamber. How much - just my guess would be a reduction of 20-25 percent as a starting point, and then keep increasing main pill area size slowly to continuing towards leaner. You may need to change your spark plugs and timing as well.
Not too sure how the engine temperature will fare compared to running straight methanol. Reducing the fuel ~20-25% running through your engine will no doubt increase temperature.