Steve:
If your shooting for bigger ci. you can do it with a stock deck [9.800"].
The tall deck 427 truck blocks require intake spacers and a taller distributor if your going to use a stock height intake.
It is also a heavy block that will not yield much more cubic inch than a standard deck.
Your question needs more information to get a more complete answer.
We are on a front engine dragster site so I will assume that is the car of choice.
I will throw some things at the wall and see if anything sticks:
1700Lb car/driver - Powerglide and a 5000 stall convertor - 4.30 rear gear and 33" tire.
I would build a .100" over bore 454 engine. [4.350 bore x 4.00" stroke = 475.5cubic inchs.]
A good set of over the counter heads like TrickFlow are a great bargin and make big power.
Camshaft with about 274 / 284* @.050" and 110* Lobe separation.
Stack injectors with alcohol and zoomies.
High 7s or low 8 second runs and no problems.
Put some more info up here and lets see what we can build.
Matt