Is the part being "locked" submersed full time in methanol? Just get occasionally wet with methanol? Or is it just used in the proximity of methanol?
I don't really know right off if methanol dissolves or degrades the effectiveness, but I'm sure the last two scenarios above are fine. As quick as methanol evaporates, I don't think it would cause an issue. In the first case however, I doubt the loctite would stick around long.
Spud